How can I get Asymmetric Waveform Ion Mobility Spectrometry for my mass spectrometer?


Three companies have a commercial interest in FAIMS for mass spectrometry. Some information is presented here for PE Sciex, Thermo Scientific and for Agilent Technologies. More details at their respective web sites.


I. AB Sciex.

AB Sciex now provides FAIMS for mass spectromtry. Press Release and more Details



Press Release - June 6, 2011

AB SCIEX, a global leader in life science analytical technologies, today announced the introduction of AB SCIEX SelexION Technology. This novel technology delivers unprecedented performance and a new dimension of selectivity in differential ion mobility spectrometry for quantitative and qualitative analysis. SelexION technology was presented at the AB SCIEX Users Meeting and is on display all week at the American Society of Mass Spectrometry (ASMS) conference in AB SCIEX's hospitality suite in Denver.

The SelexION Technology is the first differential ion mobility separation technology that possesses day-to-day reproducibility, robustness and ease of use while delivering an additional dimension of selectivity for sensitive quantitative and qualitative analyses, within a UHPLC time scale and over multiple MRMs (multiple reaction monitoring). AB SCIEX SelexION Technology significantly improves selectivity and performance for any application requiring the separation of isobaric species, isolation of challenging co-eluting contaminants and elimination of high background noise. As a result, this advancement improves data quality and accelerates sample preparation procedures.



II. Thermo Scientific.

A FAIMS for mass spectrometry may be acquired from Thermo Scientific. Details



from PRESS RELEASE October 2007

Thermo Fisher Scientific adds FAIMS Capability to Ion Trap Mass Spectrometers: Precise and reliable results for proteomics and metabolism analyses

Thermo Fisher Scientific, the world leader in serving science, announces that the Thermo Scientific FAIMS (high-Field Asymmetric waveform Ion Mobility Spectrometry) interface is now available for the Thermo Scientific industry-leading family of ion trap mass spectrometers. The FAIMS capability eliminates interferences and significantly increases the number of the total spectra that match sequences and eliminates the need for additional time-consuming separation steps. Well-suited for proteomics applications, as much as 90% of the total FAIMS spectra have been shown to match peptide sequences.

The combination of FAIMS and ion trap mass spectrometers addresses the needs of scientists working in laboratories who require more definitive results and multiple modes of separation from interferences.

Thermo Scientific ion trap mass spectrometers, when coupled with the FAIMS interface, allow users to selectively isolate target compounds based on a number of physical properties, including charge state and molecular conformation. This selection of ions occurs before the introduction of the sample into the mass spectrometer, reducing background noise, increasing selectivity and improving spectral quality.

For more information about the combined FAIMS-Ion Trap MS platform please call +1 800-532-4752, e-mail

sensitivity video on YouTube



III. Owlstone and Agilent Technologies

Owlstone and Agilent Technologies Collaborate to Explore FAIMS/TOF-MS Applications


Owlstone Nanotech Inc., a subsidiary of Advance Nanotech Inc.and Agilent Technologies announced a phase one agreement to develop Owlstone's field-asymmetric ion mobility spectrometry (FAIMS) filter as a front-end separation module for Agilent's Accurate Mass time-of-flight mass spectrometers (TOF-MS).

The goal is to determine how the systems can work together to enable identification of previously unresolved analytes. The collaboration will also explore how FAIMS can speed up liquid chromatographic separations, saving valuable analysis time.

"The collaboration with Agilent gives us the opportunity to integrate our technology onto highly sensitive mass spectrometers that are ideal for demonstrating the benefit of the uniquely high-field, fast scanning ability of our FAIMS device," said Bret Bader, Owlstone CEO. Partnerships with highly-skilled organizations like Agilent are a key part of our business strategy. We view this alliance with a recognized industry leader as a further stride in the realization of this strategy and a testament to the quality we strive to achieve at Owlstone; and we are very excited by the potential of these collaborative efforts to bring new analytical capabilities to a world-wide market."

Owlstone and Agilent have developed a FAIMS-MS system. Owlstone ultraFAIMS



News Release

SOURCE: Advance Nanotech, Inc.
June 15, 2010 12:24 ET
Owlstone Presents Pharmaceutical Application Data on Ultra-FAIMS News Release

MONTEBELLO, NY--(Marketwire - June 15, 2010) - Advance Nanotech, Inc. (OTCBB: AVNA) is pleased to announce that Owlstone has released certain results of a pharmaceutical application study using its Ultra-FAIMS technology. The results were made public at the ASMS 2010 annual conference and can be found on Owlstone's website ( under the Owlstone twitter feed (OwlstoneNano).

The aim of the study was to test whether the Owlstone Ultra-FAIMS device could provide useful ion separation for pharmaceutical applications. The results demonstrated that the Ultra-FAIMS device does deliver additional selectivity that can enhance pharmaceutical analyses by reducing or eliminating background noise and by separating co-eluding ions.

Online Book

An open-access online book "Ion Mobility Mass Spectrometry - The Next 5 Years" was released as the result of a collaboration between 30+ academics and Owlstone Inc.

In writing this book,each author has contributed a section in which they detail what they think the most important contributions have been to the field as well as what they are working on now and how they expect things to evolve in the next five years.

The book is free to access from this link: Ion Mobility Mass Spectrometry - The Next 5 Years